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Epigenetics Compound Library

Why Screen?

Screening for modulators of target proteins ● Induced pluripotent stem cell systems are at the forefront of new treatment methodologies in both the lab and the clinic.   ● Induction often requires the use of factors, especially Oct4, to establish pluripotency but is inefficient and carries risks of genetic mutation and abnormal expression.   ● Dr. Deng’s Lab designed an OCT-4 GFP reporter system and identified a known chemical forskolin (activator of adenylyl cyclase) that is able to reproduce the effects of OCT-4. By using forskolin in conjunction with other chemicals, they successfully induced pluripotent stem cells without the use of factor.

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Description & Advantages Product Citations Best Selling Libraries ● 182 Small molecule modulators ● Structurally diverse, medicinally active ,and cell permeable ● Targets HDACs, SIRTs, HATs, etc Nature, 2015,520(7547),368-72 Nature, 2015,517(7534),391-5 Nature, 2014,510(7504),283-7 Cell, 2010,142,444–455 ● Express-Pick Library ● Kinase Inhibitor Library ● Bioactive Compound Library ● Cherry Pick library

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