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| Stem Cell Control: Wnt Signaling |
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| Stem Cell Signaling Pathway |
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| Attractive Inhibitors in Stem Cell Pathway |
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| Wnt/beta-catenin Inhibitor |
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| Selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β. |
| Related Products: ICG-001, Wnt-C59, LGK-974 |
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| GSK-3 Inhibitor |
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| A hydrochloride of CHIR-99021 is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM in cell-free assays; ability to distinguish between GSK-3 and its closest homologs Cdc2 and ERK2. |
| Related Products: SB216763, Tideglusib |
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| ROCK Inhibitor |
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| A selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
| Related Products: Thiazovivin, Fasudil (HA-1077) HCl |
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