Inhibitor Expert (Inhibitors,Compound Libraries)
FDA Drug Approvals in Haematology–Oncology
Nat Rev Clin Oncol. 2019 Mar;16(3):139-141
doi:10.1038/s41571-019-0170-z
Active Ingredient Drug Name FDA-Approved Use
Pembrolizumab  >> Keytruda To treat Merkel cell cancer, hepatocellular cancer, lung cancer, cervical cancer, urothelial cancer and lymphoma
Nivolumab  >> Opdivo To treat colorectal cancer and renal cancer in combination with ipilimumab, as well as lung cancer with monotherapy
Durvalumab  >> Imfinzi First-line treatment of patients with stage III non-small cell lung cancer (NSCLC) and metastatic NSCLC
Atezolizumab  >> Tecentriq Indicated for locally advanced or metastatic urothelial carcinoma and metastatic NSCLC
Ipilimumab  >> Yervoy To treat colorectal cancer and renal cancer in combination with nivolumab
Rituximab  >> Rituxan Indicated for untreated and previously treated CD20-positive CLL,combined therapy with fludarabine and cyclophosphamide (FC)
Bevacizumab  >> Avastin Indicated in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan for women with platinum-resistant recurrent epithelial ovarian
Prucalopride  >> Motegrity To treat chronic idiopathic constipation
Gilteritinib  >> Xospata To treat the relapsed or refractory acute myeloid leukemia (AML)
Larotrectinib  >> Vitrakvi To treat patients whose cancers have a specific genetic feature (biomarker)
Glasdegib  >> Daurismo To treat newly-diagnosed AML
Revefenacin  >> Yupelri To treat chronic obstructive pulmonary disease
Lorlatinib  >> Lorbrena To treat patients with ALK-positive metastatic non-small cell lung cancer
Talazoparib  >> Talzenna To teat locally advanced or metastatic breast cancer patients with a germline BRCA mutation.
Dacomitinib  >> Vizimpro To treat metastatic non-small-cell lung cancer
Duvelisib  >> Copiktra To treat relapsed or refractory chronic lymphocytic leukemia, andsmall lymphocytic lymphoma
Elagolix  >> Orilissa For the management of moderate to severe pain associated with endometriosis
Ivosidenib  >> Tibsovo To treat patients with relapsed or refractory acute myeloid leukemia
Encorafenib  >> Braftovi To treat unresectable or metastatic melanoma
Binimetinib  >> Mektovi To treat unresectable or metastatic melanoma
Moxidectin  >> Moxidectin To treat onchocerciasis due to Onchocerca volvulus in patients aged 12 years and older
Baricitinib  >> Olumiant To treat moderately to severely active rheumatoid arthritis
Fostamatinib  >> Tavalisse To treat thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP)
Apalutamide  >> Erleada To treat a certain type of prostate cancer using novel clinical trial endpoint
Tezacaftor  >> Symdeko To treat cystic fibrosis in patients age 12 years and older
Tenofovir  >> Biktarvy

To treat infection in adults without antiretroviral treatment history or to replace current antiretroviral regimen

For research use only, not for human use.
Why Screening with FDA-approved Drug Library ?  
Looking for candidate drugs in treatment of cancer and other disease
Bortezomib is a novel therapeutic drug has shown promise for the treatment of multiple myeloma, yet its sensitivity and effectivity still have room for improvement.
 
Dr Kong Sun-Young’s lab performed a high-throughput cell-based screening using the compound library from SelleckChem and identified albendazole (drug for worm infestations) as a sensitizer for combination therapy with bortezomib in the treatment multiple myeloma.
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