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| Hot Selling Inhibitors in Apoptosis Signaling Pathway |
| Bcl-2 Inhibitor
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ABT-263 (Navitoclax) 
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| ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2. |
| Related Products: ABT-737, Obatoclax Mesylate, TW-37
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| Caspase Inhibitor
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| Z-VAD-FMK
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| Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells. |
| Related Products: Belnacasan (VX-765), PAC-1, Z-DEVD-FMK
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