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| ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. Phase 2. |
| Related Products: ABT-263, Obatoclax Mesylate, TW-37 |
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| TNF-alphaInhibitor |
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| Mdm2Inhibitor |
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| Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells. |
| Related Products: Nutlin-3a, NSC 207895 |
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