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Signaling Breakthroughs of the Year 2016 |
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Sci Signal. 2017 Jan 3;10(460) |
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Excess activity of GSK-3 may contribute to various neurological disorders, including Alzheimer's disease |
CHIR-99021 HCl against GSK-3 |
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CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM in cell-free assays; ability to distinguish between GSK-3 and its closest homologs Cdc2 and ERK2. |
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Application of insights into GPCR signaling to disorders involving the nervous system |
GPCR Compound Library |
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A unique collection of 280 GPCR small molecule compound library for GPCR screening. |
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The proinflammatory cytokine tumor necrosis factor-α (TNF-α) promotes PD-L1 stability in cancer cells |
Pomalidomide against TNF-α |
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Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. |
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Regulation of PD-L1 abundance by N-glycosylation and ubiquitination |
PD-1/PD-L1 inhibitor 1 |
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PD-1/PD-L1 inhibitor 1 is a PD-1/PD-L1 interaction inhibitor. |
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A mechanism for trehalose-dependent autophagy, showing that trehalose promoted AMPK-dependent hepatocyte autophagy and mitigated hepatic steatosis by inhibiting glucose uptake by SLC2A family transporters |
Autophagy Compound Library |
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A unique collection of 154 autophagy signaling pathway ihibitors |
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