Inhibitor Expert (Inhibitors, Modulators, Libraries)
Signaling Pathway Screening Library Catalog New Inhibitor
Signaling Breakthroughs of the Year 2016
Sci Signal. 2017 Jan 3;10(460)
Neuroscience  
   
Excess activity of GSK-3 may contribute to various neurological disorders, including Alzheimer's disease
CHIR-99021 HCl against GSK-3
LY294002
CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM in cell-free assays; ability to distinguish between GSK-3 and its closest homologs Cdc2 and ERK2.
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Application of insights into GPCR signaling to disorders involving the nervous system
GPCR Compound Library
 
A unique collection of 280 GPCR small molecule compound library for GPCR screening.
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Immunology  
   
The proinflammatory cytokine tumor necrosis factor-α (TNF-α) promotes PD-L1 stability in cancer cells
Pomalidomide against TNF-α
LY294002
Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs.
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Regulation of PD-L1 abundance by N-glycosylation and ubiquitination
PD-1/PD-L1 inhibitor 1
LY294002
PD-1/PD-L1 inhibitor 1 is a PD-1/PD-L1 interaction inhibitor.
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Cellular metabolism  
   
A mechanism for trehalose-dependent autophagy, showing that trehalose promoted AMPK-dependent hepatocyte autophagy and mitigated hepatic steatosis by inhibiting glucose uptake by SLC2A family transporters
Autophagy Compound Library
 
A unique collection of 154 autophagy signaling pathway ihibitors
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